Ligand-induced dimerization of the platelet-derived growth factor receptor
نویسندگان
چکیده
منابع مشابه
Dimerization of extracellular domains of platelet-derived growth factor receptors. A revised model of receptor-ligand interaction.
The alpha- and beta-subunits of the receptor for platelet-derived growth factor (PDGFR) were found to be autophosphorylated in the absence of ligands at high expression levels which suggests a propensity of PDGFRs to dimerize spontaneously. When the extracellular domains (ED) of both receptors were expressed and purified to homogeneity, they could be dimerized specifically by the different PDGF...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)80121-1